Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

Nanoscale. 2016 Apr 7;8(13):6981-5. doi: 10.1039/c5nr07588b.

Abstract

Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane* / chemistry
  • Cell Membrane* / metabolism
  • Cell Membrane* / ultrastructure
  • Cell Survival / drug effects
  • Diffusion
  • Doxorubicin / administration & dosage
  • Doxorubicin / pharmacokinetics
  • Drug Delivery Systems / methods*
  • Humans
  • Lactic Acid / chemistry*
  • MCF-7 Cells
  • Monocytes / ultrastructure*
  • Nanoparticles
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Particle Size
  • Polyglycolic Acid / chemistry*
  • Polylactic Acid-Polyglycolic Acid Copolymer

Substances

  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Doxorubicin