[The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study: To better understand chronic kidney disease]

Nephrol Ther. 2016 Apr:12 Suppl 1:S49-56. doi: 10.1016/j.nephro.2016.01.005. Epub 2016 Mar 11.
[Article in French]


Background: Preserving kidney function and improving the transition from chronic kidney disease to end stage is a research and healthcare challenge. The national Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort was established to identify the determinants, biomarkers and practice patterns associated with chronic kidney disease outcomes.

Methods: The study will include more than 3000 adult patients with moderate to advanced chronic kidney disease from a representative sample of 40 nephrology clinics with respect to regions and legal status, public or private. Patients are recruited during a routine visit and followed for 5 years, before and after starting renal replacement therapy. Patient-level clinical, biological, and lifestyle data are collected annually, as well as provider-level data on clinical practices, coordinated with the International Chronic Kidney Disease Outcomes and Practice Pattern Study. Blood and urine samples are stored in a biobank. Major studied outcomes include survival, patient-reported outcomes, disease progression and hospitalizations.

Results: More than 13,000 eligible patients with chronic kidney disease were identified, 60% with stage 3 and 40% with stage 4. Their median age is 72 years [interquartile range, 62-80 years], 60% are men and 38% have diabetes. By the end of December 2015, 2885 patients were included.

Conclusion: The CKD-REIN cohort will serve to improve our understanding of chronic kidney disease and provide evidence to improve patient survival and quality of life as well as health care system performances.

Keywords: Biomarkers; Biomarqueurs; Chronic kidney disease; Clinical practice; End-stage renal failure; Insuffisance rénale terminale; Maladie rénale chronique; Mortality; Mortalité; Patient-reported outcomes; Pratique clinique; Qualité de vie.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Disease Progression
  • Female
  • Follow-Up Studies
  • France / epidemiology
  • Humans
  • Information Services*
  • Kidney Failure, Chronic / epidemiology
  • Male
  • Middle Aged
  • Quality of Life*
  • Renal Insufficiency, Chronic / diagnosis
  • Renal Insufficiency, Chronic / epidemiology*
  • Renal Insufficiency, Chronic / therapy
  • Renal Replacement Therapy / methods