A mathematical model verifying potent oncolytic efficacy of M1 virus

Math Biosci. 2016 Jun:276:19-27. doi: 10.1016/j.mbs.2016.03.001. Epub 2016 Mar 11.


Motivated by the latest findings in a recent medical experiment [19] which identify a naturally occurring alphavirus (M1) as a novel selective killer targeting zinc-finger antiviral protein (ZAP)-deficient cancer cells, we propose a mathematical model to illustrate the growth of normal cells, tumor cells and the M1 virus with limited nutrient. In order to better understand biological mechanisms, we discuss two cases of the model: without competition and with competition. In the first part, the explicit threshold conditions for the persistence of normal cells (or tumor cells) is obtained accompanying with the biological explanations. The second part indicates that when competing with tumor cells, the normal cells will extinct if M1 virus is ignored; Whereas, when M1 virus is considered, the growth trend of normal cells is similar to the one without competition. And by using uniformly strong repeller theorem, the minimum effective dosage of medication is explicitly found which is not reported in [19]. Furthermore, numerical simulations and corresponding biological interpretations are given to support our results.

Keywords: M1 virus; Oncolytic virotherapy; Persistence; Stability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alphavirus*
  • Animals
  • Humans
  • Models, Theoretical*
  • Neoplasms / therapy*
  • Oncolytic Virotherapy*
  • Oncolytic Viruses*