CDK4/6 Inhibitors resTORe Therapeutic Sensitivity in HER²⁺ Breast Cancer

Cancer Cell. 2016 Mar 14;29(3):243-244. doi: 10.1016/j.ccell.2016.02.016.

Abstract

CDK4/6 inhibitors have received approval for treating hormone-positive breast tumors, but whether other aggressive cancers respond to these molecules is not yet clear. In this issue of Cancer Cell, Goel et al. (2016) report an unexpected activity of CDK4/6 inhibitors in reducing mTOR function and re-sensitizing HER2-positive cancers to EGFR/HER2 blockade.

Publication types

  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / drug therapy*
  • Cyclin-Dependent Kinase 4 / antagonists & inhibitors*
  • Cyclin-Dependent Kinase 6 / antagonists & inhibitors*
  • Drug Resistance, Neoplasm / drug effects*
  • Female
  • Humans
  • Protein Kinase Inhibitors / pharmacology*
  • Receptor, ErbB-2 / metabolism*

Substances

  • Protein Kinase Inhibitors
  • Receptor, ErbB-2
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6