Mammary Ductal Environment Is Necessary for Faithful Maintenance of Estrogen Signaling in ER⁺ Breast Cancer

Cancer Cell. 2016 Mar 14;29(3):249-250. doi: 10.1016/j.ccell.2016.02.017.


In this issue of Cancer Cell, Sflomos et al. (2016) describe a robust preclinical animal model of ER⁺ breast cancer. The authors identify the critical role of the breast microenvironment in determining hormone response of ER⁺ breast cancer cells and in driving the luminal phenotype of breast cancer.

Publication types

  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology*
  • Estrogen Receptor alpha / genetics*
  • Female
  • Humans
  • Mammary Glands, Human / pathology*
  • Tumor Microenvironment / genetics*


  • Estrogen Receptor alpha