Hyaluronic Acid in Inflammation and Tissue Regeneration

Wounds. 2016 Mar;28(3):78-88.


Hyaluronic acid (HA), the main component of extracellular matrix, is considered one of the key players in the tissue regeneration process. It has been proven to modulate via specific HA receptors, inflammation, cellular migration, and angiogenesis, which are the main phases of wound healing. Studies have revealed that most HA properties depend on its molecular size. High molecular weight HA displays anti-inflammatory and immunosuppressive properties, whereas low molecular weight HA is a potent proinflammatory molecule. In this review, the authors summarize the role of HA polymers of different molecular weight in tissue regeneration and provide a short overview of main cellular receptors involved in HA signaling. In addition, the role of HA in 2 major steps of wound healing is examined: inflammation and the angiogenesis process. Finally, the antioxidative properties of HA are discussed and its possible clinical implication presented.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use*
  • Humans
  • Hyaluronan Receptors / drug effects
  • Hyaluronic Acid / metabolism
  • Hyaluronic Acid / therapeutic use*
  • Immunosuppression Therapy / methods
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Inflammation / pathology*
  • Regeneration / drug effects*
  • Signal Transduction
  • Soft Tissue Injuries / drug therapy
  • Soft Tissue Injuries / pathology*
  • Wound Healing / drug effects*


  • Anti-Inflammatory Agents
  • Hyaluronan Receptors
  • Hyaluronic Acid