Serum Klotho Levels in Trained Athletes

Nephrourol Mon. 2016 Jan 9;8(1):e30245. doi: 10.5812/numonthly.30245. eCollection 2016 Jan.


Background: Klotho is an anti-aging protein that is predominantly secreted by the kidneys.

Objectives: The aim of the study was to measure and compare the circulating Klotho levels in the serum of trained athletes and in healthy, non-athlete controls.

Materials and methods: Thirty trained football players were enrolled and their serum Klotho levels were measured the morning after their last evening exercise training.

Results: The plasma free Klotho concentration was significantly higher in the athlete group (3.375 ± 1.48 ng/mL) compared to the non-athletes (1.39 ± 0.43 ng/mL) (P < 0.05). Serum levels of cholesterol, triglycerides, calcium, and phosphorus were not significantly different between the two groups.

Conclusions: Regular aerobic exercise could increase plasma Klotho levels, and this could be an explanation for exercise-related anti-aging effects.

Keywords: Aging; Exercise; Kidney; Serum Klotho.