[COMPARATIVE SENSITIVITY OF CHOLINESTERASES IN VERTEBRATES AND INVERTEBRATES TO HIGHLY SPECIFIC ORGANOPHOSPHORUS INHIBITORS DIISOPROPYL FLUOROPHOSPHATE (DFP) AND (2-ETHOXYMETHYL PHOSPHORYL THIOETHYL) ETHYL (METHYL) SULPHONIUM SULPHOMETHYLAT (GD-42)]

Zh Evol Biokhim Fiziol. 2015 Nov-Dec;51(6):419-26.
[Article in Russian]

Abstract

The review presents data on comparative reactivity of 68 cholinesterase preparation from various organs and tissues in a number of vertebrates and invertebrates based on sensitivity to two highly specific and most studied organophosphorus inhibitors--diisopropyl fluorophosphates (DFP) and (2-ethoxymethyl phosphoryl thioethyl) ethyl (methyl) sulphonium sulphomethylat (GD-42). Analysis of these data suggests a great diversity in enzymologic characteristics of cholinesterase preparation in representatives of vertebrates and invertebrates, this variety observed even for closely related enzymes in animals of almost the same level of development.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Cholinesterase Inhibitors / chemistry*
  • Cholinesterases / chemistry*
  • Humans
  • Isoflurophate / chemistry*
  • Organothiophosphorus Compounds / chemistry*
  • Species Specificity

Substances

  • Cholinesterase Inhibitors
  • Organothiophosphorus Compounds
  • Isoflurophate
  • methylsulfomethylate
  • Cholinesterases