Fulminant Type 1 Diabetes Mellitus Associated With Coxsackie Virus Type A2 Infection: A Case Report and Literature Review

Intern Med. 2016;55(6):643-6. doi: 10.2169/internalmedicine.55.5292. Epub 2016 Mar 15.

Abstract

A 65-year-old Japanese man presented to our hospital in June 2013 with a 6-day history of fever and fatigue, a 24-h history of thirst, and polyuria. His temperature was 37.8°C and he was alert. However, laboratory tests revealed severe hyperglycemia, undetectable C-peptide levels, and diabetic ketoacidosis. Serum antibody testing confirmed a Coxsackie virus A2 infection. A variety of viral infections are reported to be involved in the development of fulminant type 1 diabetes mellitus (FT1D). Our patient is the first reported case of FT1D associated with Coxsackie virus A2 infection and supports the etiological role of common viral infections in FT1D.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Aged
  • Antibodies, Viral / blood
  • Coxsackievirus Infections / blood
  • Coxsackievirus Infections / complications*
  • Coxsackievirus Infections / diagnosis*
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / virology
  • Diabetic Ketoacidosis / complications
  • Diabetic Ketoacidosis / diagnosis*
  • Diabetic Ketoacidosis / etiology
  • Enterovirus / immunology
  • Enterovirus / isolation & purification*
  • Fatigue / etiology
  • Fever / etiology
  • Fluid Therapy / methods
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / therapeutic use*
  • Male
  • Polyuria / etiology
  • Thirst
  • Treatment Outcome

Substances

  • Antibodies, Viral
  • Hypoglycemic Agents
  • Insulin