Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

doi:10.1186/s13073-016-0286-z

. 2016 Mar 17;8(1):30.

doi: 10.1186/s13073-016-0286-z.

Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

Edward J Fox¹, Jesse J Salk^{2

3}, Lawrence A Loeb^{2

4}

Affiliations

¹ Department of Pathology, University of Washington, Seattle, WA, 98195, USA. eddiejfox@gmail.com.
² Department of Pathology, University of Washington, Seattle, WA, 98195, USA.
³ Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, 98195, USA.
⁴ Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.

PMID: 26987311
PMCID: PMC4797182
DOI: 10.1186/s13073-016-0286-z

Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

Edward J Fox et al. Genome Med. 2016.

. 2016 Mar 17;8(1):30.

doi: 10.1186/s13073-016-0286-z.

Authors

Edward J Fox¹, Jesse J Salk^{2

3}, Lawrence A Loeb^{2

4}

Affiliations

¹ Department of Pathology, University of Washington, Seattle, WA, 98195, USA. eddiejfox@gmail.com.
² Department of Pathology, University of Washington, Seattle, WA, 98195, USA.
³ Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, 98195, USA.
⁴ Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.

PMID: 26987311
PMCID: PMC4797182
DOI: 10.1186/s13073-016-0286-z

Abstract

Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications.

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References

1. Nik-Zainal S, Alexandrov LB, Wedge DC, Van Loo P, Greenman CD, Raine K, et al. Mutational processes molding the genomes of 21 breast cancers. Cell. 2012;149:979–993. doi: 10.1016/j.cell.2012.04.024. - DOI - PMC - PubMed
1. Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415–421. doi: 10.1038/nature12477. - DOI - PMC - PubMed
1. Alexandrov LBB, Nik-Zainal S, Wedge DCC, Campbell PJJ, Stratton MRR. Deciphering signatures of mutational processes operative in human cancer. Cell Rep. 2013;3:246–259. doi: 10.1016/j.celrep.2012.12.008. - DOI - PMC - PubMed
1. Alexandrov LB, Jones PH, Wedge DC, Sale JE, Campbell PJ, Nik-Zainal S, et al. Clock-like mutational processes in human somatic cells. Nat Genet. 2015;47:1402–1407. doi: 10.1038/ng.3441. - DOI - PMC - PubMed
1. Shen JC, Rideout WM, Jones PA. High frequency mutagenesis by a DNA methyltransferase. Cell. 1992;71:1073–1080. doi: 10.1016/S0092-8674(05)80057-1. - DOI - PubMed

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[1] Nik-Zainal S, Alexandrov LB, Wedge DC, Van Loo P, Greenman CD, Raine K, et al. Mutational processes molding the genomes of 21 breast cancers. Cell. 2012;149:979–993. doi: 10.1016/j.cell.2012.04.024. - DOI - PMC - PubMed

[2] Nik-Zainal S, Alexandrov LB, Wedge DC, Van Loo P, Greenman CD, Raine K, et al. Mutational processes molding the genomes of 21 breast cancers. Cell. 2012;149:979–993. doi: 10.1016/j.cell.2012.04.024. - DOI - PMC - PubMed

[3] Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415–421. doi: 10.1038/nature12477. - DOI - PMC - PubMed

[4] Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415–421. doi: 10.1038/nature12477. - DOI - PMC - PubMed

[5] Alexandrov LBB, Nik-Zainal S, Wedge DCC, Campbell PJJ, Stratton MRR. Deciphering signatures of mutational processes operative in human cancer. Cell Rep. 2013;3:246–259. doi: 10.1016/j.celrep.2012.12.008. - DOI - PMC - PubMed

[6] Alexandrov LBB, Nik-Zainal S, Wedge DCC, Campbell PJJ, Stratton MRR. Deciphering signatures of mutational processes operative in human cancer. Cell Rep. 2013;3:246–259. doi: 10.1016/j.celrep.2012.12.008. - DOI - PMC - PubMed

[7] Alexandrov LB, Jones PH, Wedge DC, Sale JE, Campbell PJ, Nik-Zainal S, et al. Clock-like mutational processes in human somatic cells. Nat Genet. 2015;47:1402–1407. doi: 10.1038/ng.3441. - DOI - PMC - PubMed

[8] Alexandrov LB, Jones PH, Wedge DC, Sale JE, Campbell PJ, Nik-Zainal S, et al. Clock-like mutational processes in human somatic cells. Nat Genet. 2015;47:1402–1407. doi: 10.1038/ng.3441. - DOI - PMC - PubMed

[9] Shen JC, Rideout WM, Jones PA. High frequency mutagenesis by a DNA methyltransferase. Cell. 1992;71:1073–1080. doi: 10.1016/S0092-8674(05)80057-1. - DOI - PubMed

[10] Shen JC, Rideout WM, Jones PA. High frequency mutagenesis by a DNA methyltransferase. Cell. 1992;71:1073–1080. doi: 10.1016/S0092-8674(05)80057-1. - DOI - PubMed

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Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

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Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

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