Clinical comparison of 99Tcm-HMPAO labelled leucocytes and 99Tcm-nanocolloid in the detection of inflammation

Acta Radiol. 1989 Nov-Dec;30(6):633-7.


Forty-five patients with various inflammatory diseases were imaged with 99Tcm-HMPAO labelled leucocytes and 99Tcm-nanocolloid within 7 days. The overall sensitivity of 99Tcm-leucocytes was 97% and that of 99Tcm-nanocolloid 59% and both agents had a 100% specificity. The 99Tcm-leucocyte method showed reliable results in various inflammatory and infectious conditions, and seems suitable as a primary imaging method. On the contrary, 99Tcm-nanocolloid cannot be recommended for use in inflammatory bowel diseases, soft tissue abscesses or prosthetic vascular graft infections. However, 99Tcm-nanocolloid gave reliable information in inflammatory and infectious bone and joint diseases in which it had a 90% sensitivity and 100% specificity. In those lesions the 99Tcm-nanocolloid method may be useful, because it is simple, fast and cheap. Yet, further evaluation is needed.

Publication types

  • Comparative Study

MeSH terms

  • Abscess / diagnostic imaging
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Arthritis / diagnostic imaging
  • Blood Vessel Prosthesis / adverse effects
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Inflammation / diagnostic imaging*
  • Inflammatory Bowel Diseases / diagnostic imaging
  • Leukocytes
  • Male
  • Middle Aged
  • Organotechnetium Compounds*
  • Osteitis / diagnostic imaging
  • Oximes*
  • Radionuclide Imaging
  • Sensitivity and Specificity
  • Technetium Tc 99m Aggregated Albumin*
  • Technetium Tc 99m Exametazime


  • Organotechnetium Compounds
  • Oximes
  • Technetium Tc 99m Aggregated Albumin
  • Technetium Tc 99m Exametazime