An oxidase road to platelet adhesion

Blood. 2016 Mar 17;127(11):1386. doi: 10.1182/blood-2016-01-694935.


Platelet adhesion to collagen via collagen receptors is an important part of thrombosis. In this issue of Blood, Matsuura et al identify collagen receptors as previously unrecognized targets of the extracellular enzyme lysyl oxidase (LOX), the level of which is increased in myeloproliferative neoplasms (MPNs) and other conditions associated with pathological thromboses.

Publication types

  • Comment

MeSH terms

  • Animals
  • Blood Platelets / drug effects*
  • Collagen / pharmacology*
  • Platelet Activation / physiology*
  • Protein-Lysine 6-Oxidase / physiology*
  • Thrombophilia / enzymology*


  • Collagen
  • Protein-Lysine 6-Oxidase