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, 17 (9), 702-7

Chronic Hepatitis B Increases Mortality and Complexity Among HIV-coinfected Patients in South Africa: A Cohort Study

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Chronic Hepatitis B Increases Mortality and Complexity Among HIV-coinfected Patients in South Africa: A Cohort Study

K Velen et al. HIV Med.

Abstract

Objectives: To assess the effect of chronic hepatitis B on survival and clinical complexity among people living with HIV following antiretroviral therapy (ART) initiation.

Methods: We evaluated mortality and single-drug substitutions up to 3 years from ART initiation (median follow-up 2.75 years; interquartile range 2-3 years) among patients with and without chronic hepatitis B (CHB) enrolled in a workplace HIV care programme in South Africa.

Results: Mortality was increased for CHB patients with hepatitis B virus (HBV) DNA levels > 10 000 copies/mL (adjusted hazard ratio 3.1; 95% confidence interval 1.2-8.0) compared with non-CHB patients. We did not observe a similar difference between non-CHB patients and those with CHB and HBV DNA < 10 000 copies/mL (adjusted hazard ratio 0.70; 95% confidence interval 0.2-2.3). Single-drug substitutions occurred more frequently among coinfected patients regardless of HBV DNA level.

Conclusions: Our findings suggest that CHB may increase mortality and complicate ART management.

Keywords: Africa; HIV; antiretroviral therapy; hepatitis B; mortality.

Conflict of interest statement

Conflicts of Interest: All authors declare they have no conflicts of interest related this this work.

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