Plasma phthalate and bisphenol a levels and oxidant-antioxidant status in autistic children

Environ Toxicol Pharmacol. 2016 Apr:43:149-58. doi: 10.1016/j.etap.2016.03.006. Epub 2016 Mar 9.


Phthalates and bisphenol A (BPA) are endocrine disruting chemicals (EDCs) that are suggested to exert neurotoxic effects. This study aimed to determine plasma phthalates and BPA levels along with oxidant/antioxidant status in autistic children [n=51; including 12 children were diagnosed with "Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS)]. Plasma levels of BPA, di (2-ethylhexyl)-phthalate (DEHP) and its main metabolite mono (2-ethylhexyl)-phthalate (MEHP); thiobarbituric acid reactive substance (TBARS) and carbonyl groups; erythrocyte glutathione peroxidase (GPx1), thioredoxin reductase (TrxR), catalase (CAT), superoxide dismutase (SOD) and glutathione reductase (GR) activities and glutathione (GSH) and selenium levels were measured. Plasma BPA levels of children with PDD-NOS were significantly higher than both classic autistic children and controls (n=50). Carbonyl, selenium concentrations and GPx1, SOD and GR activities were higher (p<0.05); CAT activity was markedly lower in study group. BPA exposure might be associated with PDD-NOS. Intracellular imbalance between oxidant and antioxidant status might facilitate its neurotoxicity.

Keywords: Antioxidant system; Autism; Bisphenol A; Endocrine disruptors; Phthalate.

MeSH terms

  • Autistic Disorder / blood*
  • Autistic Disorder / metabolism
  • Benzhydryl Compounds / blood*
  • Catalase / metabolism
  • Child
  • Environmental Exposure / statistics & numerical data*
  • Environmental Pollutants / blood*
  • Humans
  • Phenols / blood*
  • Phthalic Acids / blood*
  • Selenium / metabolism
  • Superoxide Dismutase / metabolism
  • Thioredoxin-Disulfide Reductase / metabolism


  • Benzhydryl Compounds
  • Environmental Pollutants
  • Phenols
  • Phthalic Acids
  • phthalic acid
  • Catalase
  • Superoxide Dismutase
  • Thioredoxin-Disulfide Reductase
  • Selenium
  • bisphenol A