Diagnostic Accuracy of Optical Coherence Tomography and Scanning Laser Tomography for Identifying Glaucoma in Myopic Eyes

Ophthalmology. 2016 Jun;123(6):1181-9. doi: 10.1016/j.ophtha.2016.01.052. Epub 2016 Mar 15.


Purpose: Ruling out glaucoma in myopic eyes often poses a diagnostic challenge because of atypical optic disc morphology and visual field defects that can mimic glaucoma. We determined whether neuroretinal rim assessment based on Bruch's membrane opening (BMO), rather than conventional optic disc margin (DM)-based assessment or retinal nerve fiber layer (RNFL) thickness, yielded higher diagnostic accuracy in myopic patients with glaucoma.

Design: Case-control, cross-sectional study.

Participants: Myopic patients with glaucoma (n = 56) and myopic normal controls (n = 74).

Methods: Myopic subjects with refraction error greater than -2 diopters (D) (spherical equivalent) and typical myopic optic disc morphology, with and without glaucoma, were recruited from a glaucoma clinic and a local optometry practice. The final classification of myopic glaucoma or myopic control was based on consensus assessment by 3 clinicians of visual fields and optic disc photographs. Participants underwent imaging with confocal scanning laser tomography for measurement of DM rim area (DM-RA) and with spectral domain optical coherence tomography (SD OCT) for quantification of a BMO-based neuroretinal rim parameter, minimum rim width (BMO-MRW), and RNFL thickness.

Main outcome measures: Sensitivity of DM-RA, BMO-MRW, and RNFL thickness at a fixed specificity of 90% and partial area under the curves (pAUCs) for global and sectoral parameters for specificities ≥90%.

Results: Sensitivities at 90% specificity were 30% for DM-RA and 71% for both BMO-MRW and RNFL thickness. The pAUC was higher for the BMO-MRW compared with DM-RA (P < 0.001), but similar to RNFL thickness (P > 0.5). Sectoral values of BMO-MRW tended to have a higher, but nonsignificant, pAUC across all sectors compared with RNFL thickness.

Conclusions: Bruch's membrane opening MRW is more sensitive than DM-RA and similar to RNFL thickness for the identification of glaucoma in myopic eyes and offers a valuable diagnostic tool for patients with glaucoma with myopic optic discs.

MeSH terms

  • Area Under Curve
  • Bruch Membrane / pathology
  • Case-Control Studies
  • Cross-Sectional Studies
  • Diagnostic Techniques, Ophthalmological* / standards
  • False Negative Reactions
  • Female
  • Glaucoma, Open-Angle / diagnosis*
  • Humans
  • Intraocular Pressure
  • Male
  • Microscopy, Confocal / standards
  • Middle Aged
  • Myopia / diagnosis*
  • Nerve Fibers / pathology*
  • Optic Disk / pathology*
  • Optic Nerve Diseases / diagnosis*
  • Predictive Value of Tests
  • Reproducibility of Results
  • Retinal Ganglion Cells / pathology*
  • Sensitivity and Specificity
  • Tomography, Optical Coherence / standards
  • Vision Disorders / diagnosis
  • Visual Fields