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. 2016 Jun:126:41-6.
doi: 10.1016/j.phytochem.2016.03.005. Epub 2016 Mar 16.

Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087

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Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087

Chun-Shun Li et al. Phytochemistry. 2016 Jun.

Abstract

Seven sesquiterpene derivatives, including chaetopenoids A-F and dendryphiellin A1, and 6-methyl-(2E, 4E, 6S) octadienoic acid were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations of chaetopenoids A-D were elucidated by comparison of their CD and optical rotation data with those in the literature. Chaetopenoids A-C and E belong to the eremophilane type of sesquiterpenoids, while chaetopenoids D and F and dendryphiellin A1 have a trinor-eremophilane skeleton. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A1 was moderately active with IC50 values of 6.6 and 9.1 μg/mL, respectively.

Keywords: Araliaceae; Bioactivity; Chaetoconis sp. FT087; Endophytic fungi; Hawai’i; Osmoxylon novoguineensis; Sesquiterpenes.

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