Combined phacoemulsification and XEN45 surgery from a temporal approach and 2 incisions

Arch Soc Esp Oftalmol. 2016 Sep;91(9):415-21. doi: 10.1016/j.oftal.2016.02.006. Epub 2016 Mar 16.
[Article in English, Spanish]

Abstract

Objective: To assess the safety and effectiveness of phacoemulsification combined with XEN45 implant surgery in patients with cataract and open-angle glaucoma, with 12-month follow-up.

Methods: A prospective study conducted on 30 eyes requiring phacoemulsification with, at least, 2 medications to control intraocular pressure (IOP). Phacoemulsification combined with XEN45 implant surgery was performed within 15minutes of administering subconjunctival mitomycin C. Surgery was performed through 2 temporal incisions, separated by 90°, using the inferior to enter the XEN45 and to implant it in the superior nasal region. A record was made of the best corrected visual acuity, IOP before and 1 day, 1 month, 3 months, 6 months, 9 months, and 12 months after surgery, the number of antiglaucomatous medications, and complications.

Results: The best corrected visual acuity was 0.37±0.2 and 0.72±0.15 before and 12 months after surgery, respectively. The pre-operative IOP was 21.2±3.4mmHg, with 3.07 drugs, decreasing by 61.65% on the first day, 37.26% at 1 month, 35.05% at 3 months, 31% at 6 months, 30.6% at 9 months, and 29.34% at 12 months. The number of medications decreased by 94.57%. Complications occurred in 3 eyes, 2 of them were excluded because we could not complete the implantation (280° subconjunctival haemorrhage and XEN extrusion when trying to reposition). In a third case, the bleb was encapsulated at 5 months after surgery.

Conclusions: The phacoemulsification combined with XEN45 implant surgery can effectively reduce IOP and the number of drugs in mild-moderate open-angle glaucoma, as they rehabilitate the VA. The use of only 2 micro-invasive incisions makes it simple, quick and safe, with few complications at 12 months follow-up from surgery.

Keywords: Collagen; Colágeno; Glaucoma de ángulo abierto/cirugía; Glaucoma drainage implant; Implante de drenaje glaucoma; Intraocular pressure; Microcirugía; Microsurgery/methods; Open-angle glaucoma/surgery; Presión intraocular; Stents.

Publication types

  • Clinical Trial

MeSH terms

  • Cataract / complications
  • Collagen
  • Combined Modality Therapy
  • Gels
  • Glaucoma Drainage Implants*
  • Glaucoma, Open-Angle / complications
  • Glaucoma, Open-Angle / drug therapy
  • Glaucoma, Open-Angle / surgery*
  • Humans
  • Intraocular Pressure
  • Mitomycin / therapeutic use
  • Ophthalmic Solutions / therapeutic use
  • Phacoemulsification*
  • Prospective Studies
  • Stents
  • Surgical Wound
  • Tonometry, Ocular
  • Visual Acuity

Substances

  • Gels
  • Ophthalmic Solutions
  • Mitomycin
  • Collagen