Effect of Vitamin A Supplementation on fatigue and depression in Multiple Sclerosis patients: A Double-Blind Placebo-Controlled Clinical Trial

Iran J Allergy Asthma Immunol. 2016 Feb;15(1):13-9.


Decreasing the population and activation of inflammatory T helper cells in multiple sclerosis (MS) patients using vitamin A derivatives (retinoic acids) has been well documented. The present study determined the effect of vitamin A supplementation on psychiatric signs in MS patients. The subjects were 101 relapsing-remitting MS patients enrolled in a placebo-controlled randomized clinical trial. The treatment group was administered 25000 IU/d retinyl palmitate (RP) for 6 months followed by 10000 IU/d RP for another 6 months. The results for baseline characteristics, modified fatigue impact scale and Beck Depression Inventory-II were recorded at the beginning and end of the one-year study. The non-normal distribution data was compared between groups using a nonparametric test and normal distribution data was analyzed using a parametric test. (ClinicalTrials.gov Identifiers: NCT01417273). The results showed significant improvement in the treatment group for fatigue (p=0.004) and depression (p=0.01). Vitamin A supplementation helped during interferon therapy in the treatment process and improved psychiatric outcomes for anti-inflammatory mechanisms.

Keywords: Depression; Fatigue; Multiple sclerosis; Vitamin A.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Depression / diagnosis
  • Depression / drug therapy*
  • Dietary Supplements* / adverse effects
  • Disability Evaluation
  • Diterpenes
  • Double-Blind Method
  • Fatigue / diagnosis
  • Fatigue / drug therapy*
  • Fatigue / etiology
  • Female
  • Humans
  • Iran
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / complications
  • Multiple Sclerosis, Relapsing-Remitting / diagnosis
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Psychiatric Status Rating Scales
  • Retinyl Esters
  • Time Factors
  • Treatment Outcome
  • Vitamin A / adverse effects
  • Vitamin A / analogs & derivatives*
  • Vitamin A / therapeutic use
  • Young Adult


  • Diterpenes
  • Retinyl Esters
  • Vitamin A
  • retinol palmitate

Associated data

  • ClinicalTrials.gov/NCT01417273