Cytomegalovirus Meningitis in an Infant with Severe Combined Immunodeficiency

J Pediatr. 2016 Jun:173:235-7. doi: 10.1016/j.jpeds.2016.02.054. Epub 2016 Mar 17.

Abstract

A 35-day-old female with severe combined immunodeficiency developed cytomegalovirus (CMV) meningitis before undergoing hematopoietic stem cell transplantation. Strategies for timely diagnosis of neonates with congenital or acquired CMV infection and prevention of CMV acquisition in the era of universal newborn severe combined immunodeficiency screening are needed.

Keywords: Hematopoietic stem cell transplant.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use
  • Cytomegalovirus Infections / complications*
  • Cytomegalovirus Infections / drug therapy
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Infant, Newborn
  • Janus Kinase 3 / deficiency
  • Meningitis, Viral / complications*
  • Meningitis, Viral / diagnosis
  • Meningitis, Viral / drug therapy
  • Severe Combined Immunodeficiency / complications*
  • Severe Combined Immunodeficiency / therapy

Substances

  • Antiviral Agents
  • JAK3 protein, human
  • Janus Kinase 3