Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae

J Cell Sci Suppl. 1989;12:145-8. doi: 10.1242/jcs.1989.supplement_12.12.

Abstract

In response to DNA damage, Saccharomyces cerevisiae cells arrest the cell cycle in the G2 phase. Arrest is defective in rad9 mutants; rad9 cells divide and die without repairing the damage. Several cell cycle mutants that are defective in DNA replication arrest in G2 at the restrictive temperature; this arrest is due to the RAD9 control function. Thus RAD9 is responsible for the fact that mitosis is normally dependent upon DNA replication, a function we term a 'checkpoint'. Four additional genes have been identified that are also components of the RAD9 checkpoint.

MeSH terms

  • DNA Damage
  • DNA Replication
  • DNA, Fungal
  • Genes, Fungal
  • Interphase*
  • Mitosis
  • Mutation
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / radiation effects

Substances

  • DNA, Fungal