An autophagy-independent function for Beclin 1 in cancer

Mol Cell Oncol. 2016 Jan 2;3(1):e1030539. doi: 10.1080/23723556.2015.1030539. Epub 2015 Apr 14.

Abstract

The involvement of Beclin 1 in cancer has been attributed primarily to its role in autophagy initiation. Our recent findings identify a novel, alternative mechanism by which Beclin 1 can impact tumor progression, through the regulation of growth factor receptor signaling.