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, 80 (5), 891-901

Diosgenin Effectively Suppresses Skin Inflammation Induced by Phthalic Anhydride in IL-4/Luc/CNS-1 Transgenic Mice

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Diosgenin Effectively Suppresses Skin Inflammation Induced by Phthalic Anhydride in IL-4/Luc/CNS-1 Transgenic Mice

Ji Eun Kim et al. Biosci Biotechnol Biochem.

Abstract

To quantitatively evaluate the therapeutic effects of diosgenin (DG) and investigate the role of IL-4 on skin inflammation, alterations in luciferase-derived signal and general phenotype biomarkers were measured in IL-4/Luc/CNS-1 transgenic mice with phthalic anhydride (PA)-induced skin inflammation after treatment with DG for 4 weeks. High levels of luciferase-derived signal detected in the abdominal region and submandibular lymph node (SL) of the PA treated group was significantly decreased by 67-88% in the PA + DG cotreated group. Furthermore, the weight of the lymph node and spleen, IgE concentration, epidermis thickness, and number of infiltrated mast cells were lower in the PA + DG treated group than the PA + Vehicle treated group. Moreover, expression of IL-6 and vascular endothelial growth factor (VEGF) also decreased in the PA + DG cotreated group. These results suggest that PA-induced skin inflammation could be successfully suppressed by DG treatment in IL-4/Luc/CNS-1 Tg mice through attenuation of IL-4 and IL-6 expression, as well as decreased IgE concentration and mast cells infiltration.

Keywords: IL-4/Luc/CNS-1 transgenic mice; IgE; diosgenin; phthalic anhydride; skin inflammation.

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