Association of NOD1 and NOD2 polymorphisms with Guillain-Barré syndrome in Northern Indian population

J Neurol Sci. 2016 Apr 15:363:57-62. doi: 10.1016/j.jns.2016.02.028. Epub 2016 Feb 15.


Background: Nucleotide oligomerization domain (NOD) proteins are cytosolic pattern recognition receptors that respond to bacterial substrate and induce NF-κB activation in host. Association of NOD polymorphisms have been studied in many autoimmune disorders, however its role in Guillain-Barré syndrome (GBS) remains unknown. We have investigated NOD1 Glu266Lys and NOD2 (Arg702Trp and Gly908Arg) gene polymorphisms among patients with GBS.

Materials and method: Polymorphisms in NOD-1 (Glu266Lys) and NOD-2 (Arg702Trp and Gly908Arg) genes were studied using polymerase chain reaction-restriction fragment length polymorphism in 105 patients with GBS and 100 healthy controls.

Results: Homozygous genotype (Lys/Lys) of NOD1 was significantly associated with GBS (p=0.013); and its subtypes viz. acute motor axonal neuropathy (AMAN) and acute inflammatory demyelinating polyneuropathy (AIDP) (p=0.008 and p=0.024 respectively) than controls. In NOD2 (Arg702Trp and Gly908Arg) polymorphisms, only heterozygous genotype (Arg/Trp and Gly/Arg) showed significant association with GBS (p=0.001 and p=0.01 respectively); subtypes AMAN, acute motor-sensory axonal neuropathy (AMSAN) and AIDP showed association with heterozygote Arg702Trp (p=0.001; p=0.029 and p=0.001 respectively) whereas only AIDP was associated with heterozygote genotype Gly908Arg (p=0.003).

Conclusion: NOD1 (Glu266Lys) and NOD2 (Arg702Trp and Gly908Arg) polymorphisms were associated with an increased susceptibility to GBS. These polymorphisms could be genetic marker to GBS susceptibility.

Keywords: GBS; NOD; peripheral nervous system; polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Genetic Association Studies / methods
  • Genetic Markers / genetics
  • Guillain-Barre Syndrome / diagnosis
  • Guillain-Barre Syndrome / epidemiology*
  • Guillain-Barre Syndrome / genetics*
  • Humans
  • India / epidemiology
  • Male
  • Middle Aged
  • Nod1 Signaling Adaptor Protein / genetics*
  • Nod2 Signaling Adaptor Protein / genetics*
  • Polymorphism, Genetic / genetics*
  • Population Surveillance* / methods
  • Young Adult


  • Genetic Markers
  • NOD1 protein, human
  • NOD2 protein, human
  • Nod1 Signaling Adaptor Protein
  • Nod2 Signaling Adaptor Protein