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. 2016 Oct;30(19):2173-82.
doi: 10.1080/14786419.2016.1154052. Epub 2016 Mar 21.

Two new polyhydroxysterols produced by Fusarium solani, an endophytic fungus from Chloranthus multistachys

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Two new polyhydroxysterols produced by Fusarium solani, an endophytic fungus from Chloranthus multistachys

W Y Shen et al. Nat Prod Res. 2016 Oct.

Abstract

A highly antagonistic endophytic fungus, designated strain CL39, was originated from the leaves of Chloranthus multistachys collected in Wulong of Chongqing municipality of China in November 2015. The strain was identified as Fusarium solani based on morphological characteristics, 5.8S gene and internal transcribed spacer sequence analysis. Two new compounds, 2β, 9α-dihydroxy-5α-methoxyergosta-7, 22-diene (1), 2β, 6β-dihydroxy-5α-methoxyergosta-7, 22-diene (2) have been isolated from the culture broth of the strain. Structures of the new compounds were elucidated by detailed analysis of their spectroscopic data aided by the comparison with reported data of related derivatives, and found to belong to the polyhydroxylated steroids with a hydroxyl at C-2 instead of C-3, a rare structure among the steroids. The extract of this strain and all isolated compounds were evaluated for their antagonistic activities.

Keywords: Chloranthus multistachys; Fusarium; antagonistic activities; endophytic fungus; polyhydroxysterols.

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