Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects

BMC Res Notes. 2016 Mar 22:9:180. doi: 10.1186/s13104-016-1980-z.


Background: The seven 14-3-3 protein isoforms bind to numerous proteins and are involved in a wide variety of cellular events, including the cell cycle, cell division, apoptosis and cancer. We previously found the importance of 14-3-3 proteins in neuronal migration of pyramidal neurons in the developing cortex. Here, we test the function of 14-3-3 proteins in the development of neural crest cells in vivo using mouse genetic approaches.

Results: We found that 14-3-3 proteins are important for the development of neural crest cells, in particular for the pigmentation of the fur on the ventral region of mice.

Conclusions: Our data obtained from the 14-3-3ε/14-3-3ζ/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages.

Keywords: 14-3-3; Cre transgenic mouse; Knockout mouse; Melanocyte; Neural crest cell; Pigmentation; Weight modulation; White patch; Ywhae; Ywhaz.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 14-3-3 Proteins / deficiency*
  • 14-3-3 Proteins / metabolism
  • Animals
  • Body Weight
  • Craniofacial Abnormalities / pathology
  • Crosses, Genetic
  • Female
  • Integrases / metabolism*
  • Male
  • Mice
  • Neural Crest / metabolism
  • Pigmentation / genetics*
  • Promoter Regions, Genetic*
  • Wnt1 Protein / metabolism*


  • 14-3-3 Proteins
  • 14-3-3zeta protein, mouse
  • Wnt1 Protein
  • Wnt1 protein, mouse
  • Ywhae protein, mouse
  • Cre recombinase
  • Integrases