Change of Causative Organisms Under Antifungal Treatment in Immunosuppressed Patients With HIV-infections

Mycoses. 1989;32 Suppl 2:47-51. doi: 10.1111/j.1439-0507.1989.tb02310.x.

Abstract

Oral and esophageal candidosis are very common in HIV-infected patients. Due to the lack of efficacy of topical antimycotics in advanced stages of HIV-infection oral azoles are mainly used for treatment. Azoles most often used are ketoconazole and fluconazole. While Candida albicans clearly is the most frequently encountered yeast before and after treatment other species can be found somewhat less frequently after treatment. This especially applies to Candida glabrata. Candida spp. other than C. albicans obviously may cause manifest oral candidosis. This shift of microbes deserves the more interest as they are less susceptible to azole drugs.

Publication types

  • Review

MeSH terms

  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use*
  • Candida / drug effects*
  • Candidiasis / complications
  • Candidiasis / drug therapy
  • Candidiasis / microbiology*
  • HIV Infections / complications*
  • Humans

Substances

  • Antifungal Agents