The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness

J Steroid Biochem Mol Biol. 2017 Jan;165(Pt A):114-120. doi: 10.1016/j.jsbmb.2016.03.023. Epub 2016 Mar 18.


Glucocorticoids (GCs) are involved in a large number of the physiological changes associated with metabolic syndrome and certain psychiatric illness. Although significance is often given to the concentration of GC, its biological action is determined by the activation of intracellular GC receptors (GR). Genetic polymorphisms of the GR and the large array of GR related cofactors can directly or indirectly affect the pathophysiology and evolution of these conditions. This review will discuss the effects of GR mutations on metabolic syndrome and psychotic depression.

Keywords: Glucocorticoid receptor; Metabolic syndrome; Polymorphism; Psychiatric disorders.

Publication types

  • Review

MeSH terms

  • Biological Transport
  • Depressive Disorder / genetics
  • Glucocorticoids / metabolism
  • Humans
  • Mental Disorders / genetics
  • Mental Disorders / metabolism*
  • Metabolic Syndrome / genetics
  • Metabolic Syndrome / metabolism*
  • Mutation
  • Polymorphism, Genetic
  • Psychotic Disorders / genetics
  • Receptors, Glucocorticoid / metabolism*
  • Signal Transduction
  • Transcription, Genetic


  • Glucocorticoids
  • Receptors, Glucocorticoid