Protective Effects of Lycopene on Furan-treated Diabetic and Non-diabetic Rat Lung

Biomed Environ Sci. 2016 Feb;29(2):143-7. doi: 10.3967/bes2016.016.


We assessed the effects of furan and lycopene on the histopathological and biochemical changes on lungs, body and lung weights, and food consumption of rats. Furan and diabetes caused histopathological changes, increment in malondialdehyde levels, and decrease in antioxidant enzyme activities. Lycopene showed a protective effect against these damages, except for glutathione-S-transferase and glutathione peroxidase activities. Consequently, furan and diabetes resulted in lung toxicity. Our findings demonstrate that furan treatment resulted in more alterations in histology and biochemical parameters in diabetic rats and lycopene showed protective effects against these alterations.

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Carotenoids / pharmacology*
  • Diabetes Mellitus, Experimental / enzymology*
  • Diabetes Mellitus, Experimental / pathology
  • Furans / toxicity*
  • Lung / drug effects*
  • Lung / enzymology
  • Lung / pathology
  • Lycopene
  • Male
  • Rats, Wistar


  • Antioxidants
  • Furans
  • Carotenoids
  • Lycopene
  • furan