[Pancreatic neuroendocrine neoplasms]

Radiologe. 2016 Apr;56(4):348-54. doi: 10.1007/s00117-016-0094-x.
[Article in German]


Pancreatic neuroendocrine neoplasms (NEN) account for 1-2% of all pancreatic neoplasms and represent a rare differential diagnosis. While some pancreatic NEN are hormonally active and exhibit endocrine activity associated with characteristic symptoms, the majority are hormonally inactive. Imaging techniques such as ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) or as combined PET/CT play a crucial role in the initial diagnosis, therapy planning and control. Endoscopic ultrasound (EUS) and multiphase CT represent the reference methods for localization of the primary pancreatic tumor. Particularly in the evaluation of small liver lesions MRI is the method of choice. Somatostatin receptor scintigraphy and somatostatin receptor PET/CT are of particular value for whole body staging and special aspects of further therapy planning.

Keywords: Magnetic resonance imaging; Neuroendocrine tumors; Positron emission tomography; Review; Ultrasound.

Publication types

  • Review

MeSH terms

  • Endosonography / methods*
  • Evidence-Based Medicine
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Molecular Imaging / methods*
  • Neuroendocrine Tumors / diagnostic imaging*
  • Neuroendocrine Tumors / therapy
  • Pancreatic Neoplasms / diagnostic imaging*
  • Pancreatic Neoplasms / therapy
  • Positron Emission Tomography Computed Tomography / methods*