Improving the quantitative accuracy of cerebral oxygen saturation in monitoring the injured brain using atlas based Near Infrared Spectroscopy models

J Biophotonics. 2016 Aug;9(8):812-26. doi: 10.1002/jbio.201500302. Epub 2016 Mar 22.


The application of Near Infrared Spectroscopy (NIRS) for the monitoring of the cerebral oxygen saturation within the brain is well established, albeit using temporal data that can only measure relative changes of oxygenation state of the brain from a baseline. The focus of this investigation is to demonstrate that hybridisation of existing near infrared probe designs and reconstruction techniques can pave the way to produce a system and methods that can be used to monitor the absolute oxygen saturation in the injured brain. Using registered Atlas models in simulation, a novel method is outlined by which the quantitative accuracy and practicality of NIRS for specific use in monitoring the injured brain, can be improved, with cerebral saturation being recovered to within 10.1 ± 1.8% of the expected values.

Keywords: brain injury; diffuse optical tomography; near infrared spectroscopy.

MeSH terms

  • Brain Injuries / diagnostic imaging*
  • Brain Injuries / metabolism*
  • Humans
  • Monitoring, Physiologic
  • Oxygen / metabolism*
  • Oxygen Consumption*
  • Spectroscopy, Near-Infrared*


  • Oxygen