Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: A double-blind, randomized, clinical trial

Hypertens Pregnancy. 2016 May;35(2):217-25. doi: 10.3109/10641955.2015.1137586. Epub 2016 Mar 22.


Objective: This study aimed to estimate the effectiveness of L-arginine for preventing preeclampsia in high-risk pregnancy.

Methods: We performed a randomized, double-blind, placebo-controlled, clinical trial in patients with high-risk factors for preeclampsia. Fifty subjects received L-arginine, beginning from the 20th week of gestation. An additional 50 patients received homologated placebo.

Results: The placebo group had a higher number of cases of preeclampsia (11/47) compared with the L-arginine group (3/49, P = 0.01). Birth weight was higher in the L-arginine group and there was a smaller number of preterm births (P = 0.03).

Conclusion: L-arginine is effective for preventing preeclampsia.

Keywords: Eclampsia; gestational hypertension; oxidative stress; preeclampsia; randomized controlled trial.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Arginine / pharmacology
  • Arginine / therapeutic use*
  • Blood Pressure / drug effects*
  • Double-Blind Method
  • Female
  • Humans
  • Pre-Eclampsia / prevention & control*
  • Pregnancy
  • Pregnancy, High-Risk
  • Treatment Outcome
  • Young Adult


  • Arginine