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Randomized Controlled Trial
. 2016 May;35(2):217-25.
doi: 10.3109/10641955.2015.1137586. Epub 2016 Mar 22.

Efficacy of L-arginine for Preventing Preeclampsia in High-Risk Pregnancies: A Double-Blind, Randomized, Clinical Trial

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Randomized Controlled Trial

Efficacy of L-arginine for Preventing Preeclampsia in High-Risk Pregnancies: A Double-Blind, Randomized, Clinical Trial

E E Camarena Pulido et al. Hypertens Pregnancy. .

Abstract

Objective: This study aimed to estimate the effectiveness of L-arginine for preventing preeclampsia in high-risk pregnancy.

Methods: We performed a randomized, double-blind, placebo-controlled, clinical trial in patients with high-risk factors for preeclampsia. Fifty subjects received L-arginine, beginning from the 20th week of gestation. An additional 50 patients received homologated placebo.

Results: The placebo group had a higher number of cases of preeclampsia (11/47) compared with the L-arginine group (3/49, P = 0.01). Birth weight was higher in the L-arginine group and there was a smaller number of preterm births (P = 0.03).

Conclusion: L-arginine is effective for preventing preeclampsia.

Keywords: Eclampsia; gestational hypertension; oxidative stress; preeclampsia; randomized controlled trial.

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