Embracing the Enemy: Cell-to-Cell Force Transmission Enhances Cytotoxicity

Dev Cell. 2016 Mar 21;36(6):592-4. doi: 10.1016/j.devcel.2016.03.007.


Cells respond to the mechanical properties of their environment, but how biomechanics contributes to intercellular signaling remains unclear. Reporting in Cell, Basu et al. (2016) showed that forces exerted by cytotoxic T lymphocytes enhance the function of the pore-forming protein perforin, thereby leading to more effective target cell killing.

Publication types

  • Comment

MeSH terms

  • Membrane Glycoproteins / metabolism*
  • Perforin
  • Pore Forming Cytotoxic Proteins*
  • T-Lymphocytes, Cytotoxic


  • Membrane Glycoproteins
  • Pore Forming Cytotoxic Proteins
  • Perforin