A randomized controlled trial of 2 protocols for weaning cardiac surgical patients receiving adaptive support ventilation

J Crit Care. 2016 Jun:33:163-8. doi: 10.1016/j.jcrc.2016.01.018. Epub 2016 Jan 27.


Purpose: This study aims to compare the effectiveness of weaning with adaptive support ventilation (ASV) incorporating progressively reduced or constant target minute ventilation in the protocol in postoperative care after cardiac surgery.

Material and methods: A randomized controlled unblinded study of 52 patients after elective coronary artery bypass surgery was carried out to determine whether a protocol incorporating a decremental target minute ventilation (DTMV) results in more rapid weaning of patients ventilated in ASV mode compared to a protocol incorporating a constant target minute ventilation.

Results: Median duration of mechanical ventilation (145 vs 309 minutes; P = .001) and intubation (225 vs 423 minutes; P = .005) were significantly shorter in the DTMV group. There was no difference in adverse effects (42% vs 46%) or mortality (0% vs 0%) between the 2 groups.

Conclusions: Use of a DTMV protocol for postoperative ventilation of cardiac surgical patients in ASV mode results in a shorter duration of ventilation and intubation without evidence of increased risk of adverse effects.

Keywords: Adult; Coronary artery bypass; Critical care; Morbidity; Respiration, Artificial; Ventilator weaning.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Coronary Artery Bypass / mortality*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Postoperative Care / methods
  • Respiration, Artificial*
  • Time Factors
  • Treatment Outcome
  • Ventilator Weaning / methods*