Induced pluripotent stem cells: at the heart of cardiovascular precision medicine

Nat Rev Cardiol. 2016 Jun;13(6):333-49. doi: 10.1038/nrcardio.2016.36. Epub 2016 Mar 24.


The advent of human induced pluripotent stem cell (hiPSC) technology has revitalized the efforts in the past decade to realize more fully the potential of human embryonic stem cells for scientific research. Adding to the possibility of generating an unlimited amount of any cell type of interest, hiPSC technology now enables the derivation of cells with patient-specific phenotypes. Given the introduction and implementation of the large-scale Precision Medicine Initiative, hiPSC technology will undoubtedly have a vital role in the advancement of cardiovascular research and medicine. In this Review, we summarize the progress that has been made in the field of hiPSC technology, with particular emphasis on cardiovascular disease modelling and drug development. The growing roles of hiPSC technology in the practice of precision medicine will also be discussed.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / prevention & control
  • Cell Differentiation
  • Cellular Reprogramming Techniques
  • Drug Discovery
  • Endothelial Cells / cytology
  • Humans
  • Induced Pluripotent Stem Cells*
  • Models, Cardiovascular*
  • Myocytes, Cardiac / cytology
  • Myocytes, Smooth Muscle / cytology
  • Precision Medicine*