Caveolae and Caveolin-1 Integrate Reverse Cholesterol Transport and Inflammation in Atherosclerosis

Int J Mol Sci. 2016 Mar 22;17(3):429. doi: 10.3390/ijms17030429.


Lipid disorder and inflammation play critical roles in the development of atherosclerosis. Reverse cholesterol transport is a key event in lipid metabolism. Caveolae and caveolin-1 are in the center stage of cholesterol transportation and inflammation in macrophages. Here, we propose that reverse cholesterol transport and inflammation in atherosclerosis can be integrated by caveolae and caveolin-1.

Keywords: atherosclerosis; caveolae; caveolin-1; inflammation; reverse cholesterol transport.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Atherosclerosis / metabolism*
  • Biological Transport, Active
  • Caveolae / metabolism*
  • Caveolin 1 / metabolism*
  • Cholesterol / metabolism*
  • Humans
  • Inflammation / metabolism


  • Caveolin 1
  • Cholesterol