Intrapolyp steroid injection for nasal polyposis: Randomized trial of safety and efficacy

Laryngoscope. 2016 Aug;126(8):1730-5. doi: 10.1002/lary.25945. Epub 2016 Mar 24.


Objectives/hypothesis: Local and systemic steroid treatment is the mainstay of therapy for nasal polyposis. This study aims to evaluate the safety and effectiveness of intrapolyp steroid injection on nasal polyposis and to compare the outcomes with short-term oral steroid treatment.

Study design: Prospective, randomized, controlled endoscopic clinical trial.

Methods: Ninety patients with nasal polyps were randomly assigned in a 1:1 ratio to receive oral prednisolone 1 mg/kg/day, tapering by 5 mg/day, for 2 weeks, or to receive intrapolyp steroid injection (40 mg/mL triamcinolone, 1 mL) for up to five times with intervals of 1 week. Both groups received fluticasone propionate nasal drops twice daily for 12 weeks after initial treatment. Total nasal symptoms scores and total nasal polyp scores of both groups were evaluated before and 3 and 6 months after treatment, whereas computed tomography (CT) scores were evaluated before and 6 months after treatment. Also, plasma cortisol and adrenocorticotropic hormone (ACTH) levels of the patients in the intrapolyp steroid injection group were evaluated before, during, and after treatment.

Results: A total of 211 injections were given to 45 patients, and no serious complications were observed. Both groups showed significant decrease in symptom score, polyp score, and CT score (P > 0.001), with no significant difference between groups (P > 0.05). Plasma cortisol and ACTH levels of the injected patients were in normal limits before treatment, 1 week after the first injection, and 1 week after the last injection.

Conclusion: Intrapolyp steroid injection appears to be an effective and safe method for treatment of nasal polyps, with comparable results to oral short-term steroid treatment.

Level of evidence: 1b. Laryngoscope, 126:1730-1735, 2016.

Keywords: Nasal polyposis; intrapolyp steroid injection; oral steroids; plasma ACTH level; plasma cortisol level; visual loss.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Female
  • Glucocorticoids / administration & dosage*
  • Glucocorticoids / adverse effects
  • Humans
  • Injections, Intralesional
  • Male
  • Middle Aged
  • Nasal Polyps / drug therapy*
  • Prednisolone / administration & dosage*
  • Prednisolone / adverse effects
  • Prospective Studies
  • Treatment Outcome
  • Triamcinolone / administration & dosage*
  • Triamcinolone / adverse effects
  • Young Adult


  • Glucocorticoids
  • Triamcinolone
  • Prednisolone