The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy

N Am J Med Sci. 2016 Jan;8(1):40-6. doi: 10.4103/1947-2714.175206.

Abstract

Background: Rheumatoid arthritis (RA) is a very complicated autoimmune disease with apparent synovial hyperplasia and cartilage and bone destruction.

Aims: In the present study, we aimed to determine whether the pathogenesis of RA correlates with food allergy and which allergen(s) are relevant.

Materials and methods: We used type-II collagen (CII) to induce arthritis (collagen-induced arthritis, CIA) model in Wistar rats, and the development of arthritis was evaluated accordingly by scoring system. Proinflammatory cytokine levels in plasma were measured by enzyme-linked immunosorbent assay (ELISA), and concentrations of circulating immune complexes (CICs) were analyzed by C1q solid phase method. Furthermore, food-specific immunoglobulin G (IgG) and immunoglobulin E (IgE) levels were determined in the CIA model.

Results: In the CIA model, we found that levels of tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1, IL-6, and IL-17, as well as CICs, were elevated significantly. Moreover, concentrations of milk- or egg-specific IgG and IgE were enhanced strikingly in CIA rats.

Conclusion: The results suggest that pathogenesis of RA correlates closely to increased egg- or milk-specific antibodies.

Keywords: Egg allergen; food allergy; milk allergen; proinflammatory cytokines; rheumatoid arthritis (RA).