Zika virus: epidemiology, clinical features and host-virus interactions

Microbes Infect. 2016 Jul-Aug;18(7-8):441-9. doi: 10.1016/j.micinf.2016.03.009. Epub 2016 Mar 22.


Very recently, Zika virus (ZIKV) has gained a medical importance following the large-scale epidemics in South Pacific and Latin America. This paper reviews information on the epidemiology and clinical features of Zika disease with a particular emphasis on the host-virus interactions that contribute to the pathogenicity of ZIKV in humans.

Keywords: Arbovirus; Epidemiology; Host-pathogen interactions; Innate immunity; Vector; ZIKA.

Publication types

  • Review

MeSH terms

  • Host-Pathogen Interactions*
  • Humans
  • Latin America / epidemiology
  • Pacific Islands / epidemiology
  • Zika Virus / pathogenicity*
  • Zika Virus Infection / epidemiology*
  • Zika Virus Infection / pathology*
  • Zika Virus Infection / virology