Background: Reversible cerebral vasoconstriction syndrome (RCVS) has been associated with multiple medications, cocaine, pregnancy, migraine, and other conditions.
Objectives: RCVS associated with interferon beta use has never before been described.
Methods: We describe the case of a 20-year-old female who developed acute onset severe headache and was found to have subarachnoid hemorrhage 2 months after initiating Rebif (Interferon beta-1a) for multiple sclerosis (MS). Cerebral angiography showed multiple areas of distal stenosis and dilatation with radiographic resolution 1 month later.
Results/conclusions: This is the first case report of RCVS in an MS patient treated with Rebif.
Keywords: Beta-interferon; Rebif; multiple sclerosis; reversible cerebral vasoconstriction syndrome.
© The Author(s), 2016.