Protein quality control in the nucleus

Curr Opin Cell Biol. 2016 Jun:40:81-89. doi: 10.1016/ Epub 2016 Mar 22.


The nucleus is the repository for the eukaryotic cell's genetic blueprint, which must be protected from harm to ensure survival. Multiple quality control (QC) pathways operate in the nucleus to maintain the integrity of the DNA, the fidelity of the DNA code during replication, its transcription into mRNA, and the functional structure of the proteins that are required for DNA maintenance, mRNA transcription, and other important nuclear processes. Although we understand a great deal about DNA and RNA QC mechanisms, we know far less about nuclear protein quality control (PQC) mechanisms despite that fact that many human diseases are causally linked to protein misfolding in the nucleus. In this review, we discuss what is known about nuclear PQC and we highlight new questions that have emerged from recent developments in nuclear PQC studies.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • DNA Replication
  • Eukaryotic Cells / metabolism*
  • Humans
  • Nuclear Proteins / metabolism
  • Protein Folding
  • RNA, Messenger / metabolism
  • Transcription, Genetic
  • Yeasts / cytology
  • Yeasts / metabolism


  • Nuclear Proteins
  • RNA, Messenger