Overview of Biologics

Spine (Phila Pa 1976). 2016 Apr:41 Suppl 7:S10. doi: 10.1097/BRS.0000000000001423.


Biologics in the appropriate biomechanical environment provide viable bone graft substitutes for repair of injured bone while promoting bone formation and osseointegration. Surgeons must recall the basics of bone structure, the principles of Wolff's law, and the components and steps of new bone formation to optimize the fusion environment and to maximize patient outcomes.

Publication types

  • Review

MeSH terms

  • Biological Products*
  • Bone Regeneration / physiology*
  • Bone Substitutes*
  • Bone Transplantation*
  • Humans
  • Stem Cells
  • Tissue Scaffolds


  • Biological Products
  • Bone Substitutes