The Molecular Harbingers of Early Mammalian Embryo Patterning

Cell. 2016 Mar 24;165(1):13-15. doi: 10.1016/j.cell.2016.03.005.


Random or not, the mechanisms at play during the first cell-fate determination in mammalian embryos have been debated for years. Studies by Goolam et al. and White et al. shed new light on the molecular mechanisms underlying the intrinsic biases that lead to non-random lineage segregation in early mammalian development.

Publication types

  • Comment

MeSH terms

  • Animals
  • Body Patterning
  • Cell Differentiation*
  • Cell Lineage
  • Embryo, Mammalian*