Types of Ubiquitin Ligases

Cell. 2016 Mar 24;165(1):248-248.e1. doi: 10.1016/j.cell.2016.03.003.


Ubiquitination is a post-translational modification of proteins involved in a variety of cellular processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.

MeSH terms

  • Animals
  • Humans
  • Protein Processing, Post-Translational
  • Proteins / metabolism
  • Ubiquitin-Conjugating Enzymes / chemistry*
  • Ubiquitin-Conjugating Enzymes / metabolism*
  • Ubiquitination


  • Proteins
  • Ubiquitin-Conjugating Enzymes