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Comparative Study
. 2016 Jun;161(6):1691-5.
doi: 10.1007/s00705-016-2840-9. Epub 2016 Mar 26.

Genomic, Pathogenic, and Antigenic Comparisons of Getah Virus Strains Isolated in 1978 and 2014 in Japan

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Comparative Study

Genomic, Pathogenic, and Antigenic Comparisons of Getah Virus Strains Isolated in 1978 and 2014 in Japan

Manabu Nemoto et al. Arch Virol. .

Abstract

A Getah virus strain isolated during an outbreak in racehorses in Japan in 2014 (14-I-605) was compared with the vaccine strain isolated in 1978 (MI-110). A comparison of the genome sequences of these strains revealed seven amino acid substitutions in non-structural protein 3, and one or two substitutions in each of other non-structural proteins. In contrast, the structural proteins were highly conserved (99.8-99.9 % amino acid sequence identity). Horse antisera raised against the MI-110 strain showed similar virus-neutralization titers against both MI-110 and 14-I-605 strains (512 and 256, respectively). Therefore, antigenic mutation was probably not a direct cause of the outbreak that occurred in 2014.

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