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, 31 (5), 977-86

Periodontitis Is Associated With Rheumatoid Arthritis: A Study With Longstanding Rheumatoid Arthritis Patients in Korea

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Periodontitis Is Associated With Rheumatoid Arthritis: A Study With Longstanding Rheumatoid Arthritis Patients in Korea

In Ah Choi et al. Korean J Intern Med.

Abstract

Background/aims: A cross-sectional study was undertaken to investigate the association between severity of periodontitis and clinical manifestation of rheumatoid arthritis (RA).

Methods: Two hundred sixty-four RA patients and 88 age- and sex-matched controls underwent dental exam. Additionally, clinical manifestations including disease activity and anti-citrullinated protein antibodies were evaluated in RA patients.

Results: The prevalence of moderate or severe periodontitis was higher in RA patients compared to controls (63.6% vs 34.1%, p < 0.001). In markers of periodontal inflammation, bleeding on probing was correlated with disease activity score 28 (r = 0.128, p = 0.041), RA disease duration (r = 0.211, p = 0.001), erythrocyte sedimentation rate (ESR; r = 0.141, p = 0.023), anti-cyclic citrullinated peptide antibody (r = 0.183, p = 0.009), and anti-citrullinated α-enolase peptide-1 antibody (r = 0.143, p = 0.025). Gingival index was correlated with RA duration (r = 0.262, p < 0.001), ESR (r = 0.162, p = 0.009), anti-cyclic citrullinated peptide antibody (r = 0.203, p = 0.004) and anti-citrullinated α-enolase peptide-1 antibody (r = 0.225, p < 0.001). Periodontal structural damage represented by probing pocket depth and clinical attachment level were less in RA patients with human leukocyte antigen (HLA)-DRB1 shared epitope compared than those without shared epitope (p = 0.005 and p =0.006, respectively).

Conclusions: The prevalence of moderate or severe periodontitis was increased in RA patients compared to controls. Periodontal inflammation was correlated with RA disease duration, ESR, and anti-citrullinated protein antibodies. Periodontal structural damage was less in RA patients with HLA-DRB1 shared epitope.

Keywords: Arthritis, rheumatoid; Periodontitis.

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1.
Figure 1.
(A) Probing pocket depth (PPD) was significantly lower in rheumatoid arthritis (RA) patients with HLA-DRB1 shared epitope than in those without HLA-DRB1 shared epitope (mean ± SD, 1.88 ± 0.37 mm vs. 2.05 ± 0.34 mm, p = 0.005). (B) Clinical attachment level (CAL) was significantly lower in RA patients with HLA-DRB1 shared epitope than in those without HLA-DRB1 shared epitope (3.09 ± 0.77 mm vs. 3.48 ± 0.91 mm, p = 0.006). Bars represent mean. SE, shared epitope.

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