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. 2016 May;15(6):597-609.
doi: 10.1016/S1474-4422(16)00015-6. Epub 2016 Mar 24.

Neurological Prognostication of Outcome in Patients in Coma After Cardiac Arrest

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Neurological Prognostication of Outcome in Patients in Coma After Cardiac Arrest

Andrea O Rossetti et al. Lancet Neurol. .
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Erratum in

  • Corrections.
    Lancet Neurol. 2016 Jun;15(7):656. doi: 10.1016/S1474-4422(16)30033-3. Epub 2016 Apr 13. Lancet Neurol. 2016. PMID: 27086084 No abstract available.


Management of coma after cardiac arrest has improved during the past decade, allowing an increasing proportion of patients to survive, thus prognostication has become an integral part of post-resuscitation care. Neurologists are increasingly confronted with raised expectations of next of kin and the necessity to provide early predictions of long-term prognosis. During the past decade, as technology and clinical evidence have evolved, post-cardiac arrest prognostication has moved towards a multimodal paradigm combining clinical examination with additional methods, consisting of electrophysiology, blood biomarkers, and brain imaging, to optimise prognostic accuracy. Prognostication should never be based on a single indicator; although some variables have very low false positive rates for poor outcome, multimodal assessment provides resassurance about the reliability of a prognostic estimate by offering concordant evidence.

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