Prognostic Significance of Right Bundle Branch Block for Patients with Acute Myocardial Infarction: A Systematic Review and Meta-Analysis

Med Sci Monit. 2016 Mar 27:22:998-1004. doi: 10.12659/msm.895687.


Background: The aim of the current meta-analysis was to assess the effect of right bundle branch block (RBBB) on mortality outcome in patients with acute myocardial infarction (AMI).

Material/methods: Embase, PubMed, and Cochrane databases were searched through January 2015 using the keywords "RBBB", "mortality", "AMI", "Coronary Heart Disease", and "cardiovascular". An odds ratio (OR) of RBBB on mortality endpoints was calculated using random-effects models.

Results: RBBB was associated with significantly increased overall mortality in patients with AMI. The OR of RBBB for deaths was 1.56 [95% confidence interval (CI), 1.44 to 1.68, p<0.001]. Moreover, RBBB showed a considerable effect on both in-hospital mortality (OR: 1.94, 95% CI: 1.60 to 2.37, p=0.002) and long-term mortality (OR: 1.49, 95% CI: 1.37 to 1.62, p<0.001).

Conclusions: RBBB is associated with an increased risk of all-cause mortality and indicates a poorer prognosis in patients with AMI.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Bundle-Branch Block / complications*
  • Bundle-Branch Block / mortality
  • Confidence Intervals
  • Humans
  • Myocardial Infarction / complications*
  • Myocardial Infarction / mortality
  • Prognosis
  • Publication Bias
  • Risk Factors