Hepatic Perfusion Therapy

Surg Clin North Am. 2016 Apr;96(2):357-68. doi: 10.1016/j.suc.2015.12.005.


Isolated hepatic perfusion uses the unique vascular supply of hepatic malignancies to deliver cytotoxic chemotherapy. The procedure involves vascular isolation of the liver and delivery of chemotherapy via the hepatic artery and extraction from retrohepatic vena cava. Benefits of hepatic perfusion have been observed in hepatic metastases of ocular melanoma and colorectal cancer and primary hepatocellular carcinoma. Percutaneous and prophylactic perfusions are avenues of ongoing research.

Keywords: Colorectal cancer; Hepatic metastases; Hepatocellular carcinoma; Isolated hepatic perfusion; Melanoma; Percutaneous hepatic perfusion; Regional therapies.

Publication types

  • Review

MeSH terms

  • Chemotherapy, Cancer, Regional Perfusion* / methods
  • Humans
  • Liver Neoplasms / drug therapy*
  • Patient Selection