Review: Ras GTPases and myosin: Qualitative conservation and quantitative diversification in signal and energy transduction

Biopolymers. 2016 Aug;105(8):422-30. doi: 10.1002/bip.22840.

Abstract

Most GTPases and many ATPases belong to the P-loop class of proteins with significant structural and mechanistic similarities. Here we compare and contrast the basic properties of the Ras family GTPases and myosin, and conclude that there are fundamental similarities but also distinct differences related to their specific roles. © 2016 Wiley Periodicals, Inc. Biopolymers 105: 422-430, 2016.

Keywords: P-loop; Ras GTPases; myosin; switch I; switch II.

Publication types

  • Review

MeSH terms

  • Animals
  • Energy Metabolism / physiology*
  • Humans
  • Myosins* / chemistry
  • Myosins* / metabolism
  • Protein Structure, Secondary
  • Structure-Activity Relationship
  • ras Proteins* / chemistry
  • ras Proteins* / metabolism

Substances

  • Myosins
  • ras Proteins