High-Throughput Screening Protocol for the Coupling Reactions of Aryl Halides Using a Colorimetric Chemosensor for Halide Ions

Min Sik Eom; Jieun Noh; Han-Sung Kim; Soyeon Yoo; Min Su Han; Sunwoo Lee

doi:10.1021/acs.orglett.6b00300

High-Throughput Screening Protocol for the Coupling Reactions of Aryl Halides Using a Colorimetric Chemosensor for Halide Ions

Org Lett. 2016 Apr 15;18(8):1720-3. doi: 10.1021/acs.orglett.6b00300. Epub 2016 Mar 28.

Authors

Min Sik Eom¹, Jieun Noh², Han-Sung Kim², Soyeon Yoo¹, Min Su Han¹, Sunwoo Lee²

Affiliations

¹ Department of Chemistry, Gwangju Institute of Science of Technology (GIST) , Gwangju 61005, Republic of Korea.
² Department of Chemistry, Chonnam National University , Gwangju 61186, Republic of Korea.

PMID: 27019333
DOI: 10.1021/acs.orglett.6b00300

Abstract

Mercury complex of 4-(2-pyridylazo)resorcinol (PAR-2Hg(2+)), a halide-ion chemosensor, was prepared and its efficiency as a tool for high-throughput screening (HTS) of transition-metal-catalyzed coupling reactions was investigated. It showed a high selectivity for halide ions. When the PAR-2Hg(2+) complex was used in the Suzuki coupling reaction and C-H activated coupling reaction with aryl bromides, the quantitative and qualitative conversions of aryl halides were obtained from the reaction mixture color change.

Publication types

Research Support, Non-U.S. Gov't